Atractyloside is synthesized by some plant species in the daisy family e. The potential anti helicobacter pylori and antioxidant. Toxic effects of some medicinal plants used in moroccan. Albizia gummifera is a deciduous tree with a flattened, open crown, growing up to 30 metres tall. Actaea racemosa, aloe barbadensis, atractylis gummifera, callilepsis laureola, camellia sinensis, centella asiatica, chelidonium majus, ephedra sinica, garcinia cambogia, hypericum perforatum. Milk thistle silybum marianum is a plant from the aster family. A sample of the 100g of atractylis root named lot1, was prepared by cutting very small and thin slices of root. Akram, et al antiinflammatory, antipyretic and acute toxicity effects of nbutanol extract of atractylis flava desf in rats 764. J shows that it is a rich source of flavonoids including apigenin, cirsimaritin, and various novel compounds 3, 4, and 5. Plants of atractylis gummifera grown from seeds were brought at an age of 220 weeks into a liquid culture supplied with carrier free 3%sulfate. Request pdf on jan 26, 2019, kenza mejdoub and others published chemical variability of atractylis gummifera essential oils at three developmental.
Atractylis gummifera is not the only source of atr and catr in the genus atractylis or even in the asteraceae family. Ag is a toxic plant widely used in maghreb and of provokes frequent poisoning in tunisia especially of children of 412 years ben. Of all the natural remedies used for hep b, milk thistle is the most popular, and the most tested. These studies made it possible to draw a clinical table related to the ingestion of atractylis gummifera. Files are available under licenses specified on their description page. The gi tract is composed of organs and tissues that have diverse forms and functions. Toxicity of atrs has long been recognized, since at least the first century a. Hypoglycemia in infants and children advances in pediatrics. Validated method for quantifying atractyloside and. This table includes a phase of latency of 24 h to 48 h before the appearance of the first signs of the intoxication. The root sample was immersed in 200ml of distilled water.
Pharmacognosy journal, vol 10, issue 4, julaug, 2018 extraction the collected whole plant atractylis flava was airdried and powdered. The record derives from tica data supplied on 20120211 which reports it as an accepted name record fb751e346b3d4d3f92aa976d8a3cb73e with original publication details. Pdf atractylis gummifera and centaurea ornata in the. No specific pharmacological treatment for atractylis gummifera intoxication is yet. Atractylis gummifera masticogna laticifera flora italiana. Atractylis gummifera has been traditionally used as a natural antipyretic, diuretic, and emetic in north africa and the mediterranean, and a secretion from the plant is occasionally consumed by children as chewing gum 191,192. Atractylis gummifera the purpose of this technique was to study the impact of six successive dilutions on toxicity of atractylis gummifera root extract table i. Advertizing synonyms atractylis gummifera report a problem. Atractylodes is used for indigestion, stomachache, bloating, fluid retention, diarrhea, loss of appetite, weight loss due to cancer, allergies to dust mites, and joint pain rheumatism. Biochemical investigation of atractylis gummifera l. Atractylis is a genus of plants in the daisy family. Giorgio venturini tradclaude leray, carlina gummifera. Drugrelated hepatotoxicity and acute liver failure. This follows accidental ingestion of the sweetish rhizome of.
Thus, hypoglycemia can be viewed as a failure of one these fasting systems or an abnormality in one of the hormones that controls these systems. Members contain atractyloside which inhibits adenine nucleotide translocase. The pathogenesis of liver injury includes direct hepatotoxicity and idiosyncratic reactions for most drugs, although for. The toxicity of atractylis gummifera resides in atractyloside and carboxyatractyloside, two diterpenoid glucosides capable of inhibiting mitochondrial oxidative phosphorylation.
Callilepis laureola, xanthium strumarium, iphiona alsoeri, and pascalia glauca history. All structured data from the file and property namespaces is available under the creative commons cc0 license. The straight, cylindrical bole can be up to 100cm in diameter. Mastic obtained from pistacia lentiscus is used in high grade varnishes, as a fixative in perfumes, tooth pastes, glue especially for false beards, embalming, a temporary filling for teeth etc. Most adults shouldnt get more than 4,000 milligrams per day. Title protabase plant resources of tropical africa. Chemical variability of atractylis gummifera essential oils at three.
In previous papers it was shown that atractyloside, a glycoside formerly called katractylate extracted from the rhizome of atractylis gummifera, the aglycone of which contains the. Antiinflammatory, antipyretic and acute toxicity effects. Atractylis is native to the greater mediterranean region southern europe, the middle east, north africa, and the canary islands. As a copy of the translation by julius berendes in 1902, it has entered the public domain in the united states and various other countries. Asteraceae is a thistle located in the mediterranean. Plant remedies, despite their innocuity reputation, are implicated in adverse events. The child was discharged with residual renal insufficiency 12. It can cause seizures, coma, permanent brain damage, and death. Attenuation of toxic power of atractylis gummifera european. Masticogna laticifera ricerca di altre informazioni sul web.
Asteraceae is a thistle distributed worldwide but especially abundant in the mediterranean regions, in northern africa algeria, morocco. Due to its unique position, vast variety of mountains and substrates and its mild climate, the island is rich in species. To assess the extent and severity of poisoning by atractylis gummifera l. Asteraceae is a thistle located in the mediterranean regions. Bibliography of agriculture biological abstracts georef life sciences collection selected water resources abstracts chemical abstracts vols. Atractylis gummifera is a plant belonging to the asteraceae family which is. The scanned text used to begin the current translation project was obtained from. Its in more than 600 meds, including many cold and flu drugs. Egusi melon pdf egusi melon is cultivated in portions of west africa, especially in western nigeria, for the food in the seed and as a crop interplanted with maize. This herb is a common ingredient in supplement blends that promote liver health. The roots of atractylis gummifera, a mediterranean member of the compositae called masticogna in sicily and musciurida in sardinia, contain potassium atractylate, which is a glycoside. Several metabolic systems are activated during fasting to prevent hypoglycemia. This name is the accepted name of a species in the genus atractylis family compositae. Atractylis gummifera is a cosmopolitan species that is particularly abundant in the mediterranean regions.
Carlina gummifera wikispecies, free species directory. Though the toxicity of atractylis gummifera is well known, its ingestion. The record derives from tica data supplied on 20120211 which reports it as an accepted name record 936200f2be464a3eab990b18dc157b9e with original publication details. Hepatotoxicity of herbal medicinal products semantic scholar. The poisonous effect of the distaff thistle and by extension atractyloside is well documented in history. The most common cause of druginduced alf in children is acetaminophen 15% of all alf in children in the united kingdom and the united states, whereas other drugs such as antituberculous and antiepileptic therapy account for 5%. A compound from xanthium strumarium and atractylis gummifera with plant growth inhibiting properties. Toxic hepatitis with an acute onset is well known and commences a few.
Inhibition of phosphorylation by atractyloside nature. Despite the plants wellknown toxicity, its ingestion continues to be a common cause of poisoning. Hypoglycemia is an important problem in infants and children. A gum obtained from the plant is used as an adulteration for mastic. Index of taxa indice delle specie tutte le famiglie. Acetylation of the two free hydroxyl groups of atr, october 0. This is the profile for the plant atractylis gummifera stemless atractylis xewk talmixta. Atractylis gummifera and centaurea ornata in the province of badajoz extremadura, spainethnopharmacological importance and toxicological risk. It includes the esophagus, stomach, small intestine, large intestine, colon. Silymarin is the active ingredient in milk thistle that is likely responsible for its medicinal. Each plant profile in the database contains nomenclature info, botanical data, plant description, large, highresolution pictures, images and photos of the plants and its parts. Toxic hepatitis with an acute onset is well known and commences a few hours after ingestion, accompanied by abdominal.
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